Building an Interoperable DSCSA Compliance Ecosystem: How Amatheon Animal Health Turned Compliance Into a Competitive Advantage

For national distributors, DSCSA is often treated as a requirement to satisfy, not a strategic opportunity. Amatheon Animal Health saw it differently. Working with LSPedia and RF-SMART, the veterinary pharmaceutical distributor built a fully interoperable compliance ecosystem inside its existing NetSuite ERP. The result was faster fulfillment, near-perfect accuracy, and an industry award to show for it.h2

The Challenge: Compliance Without a Native Toolkit

Amatheon Animal Health is a leading national distributor of veterinary pharmaceuticals, serving more than 10,000 specialty and general veterinary hospitals across the U.S. The company distributes controlled, cold-chain, and specialty products — categories where speed and accuracy aren't negotiable.

As the DSCSA compliance deadline approached, Amatheon ran into a familiar wall: NetSuite, its enterprise ERP, had no native tools for EPCIS data or DSCSA workflows. Manual data entry and isolated tracking systems made real-time traceability difficult and risked discrepancies between the warehouse floor and compliance records. The challenge wasn't just technical. It was operational. Every step, from inbound receiving to outbound fulfillment, needed to keep flowing without disrupting daily service to thousands of veterinary hospitals.

Amatheon wanted more than a compliant workaround. The goal was to turn DSCSA alignment into a genuine competitive advantage: faster fulfillment, error-free accuracy, and stronger trust across the veterinary supply chain.

The Solution: A Tri-Party Integration Built Around OneScan

LSPedia and RF-SMART collaborated with Amatheon to design and deploy a seamless, cloud-based integration linking LSPedia's OneScan compliance platform with RF-SMART's automation suite, all inside NetSuite ERP.

Real-time serialization and verification. Every warehouse transaction now carries serialization and product verification automatically, closing the gap between physical activity and compliance records.

Automated EPCIS interoperability. OneScan generates and exchanges EPCIS files automatically, eliminating duplicate manual entry between fulfillment and compliance systems.

Mobile-driven accuracy. RF-SMART's mobile tools capture item dimensions, photos, and shipment data at the point of activity, creating an error-proof feedback loop that flows straight into OneScan.

The rollout followed an iterative development cycle, with all three partners collaborating continuously to make sure regulatory and operational requirements were met before full go-live.

"Partnering with LSPedia and RF-SMART allowed us to transform regulatory requirements into a competitive advantage,” said David Yankana, Director of Operations at Amatheon. “Our teams share a mission of protecting patients and ensuring integrity at every point in the supply chain."

The Results: Compliance That Pays for Itself

The integration delivered results that extended well beyond the compliance checkbox:

• 40% increase in order throughput, driven by optimized picking and real-time task allocation

• 60% faster replenishment cycles, from automated bin management in high-turnover zones

• 99% pick accuracy with near-zero downtime in fulfillment operations

• Complete DSCSA serialization and EPCIS interoperability, safeguarding authenticity and patient safety

The achievement earned Amatheon the Supply Chain Excellence Award from Logistics & Supply Chain Magazine in 2025, recognition for building one of the industry's most advanced, fully interoperable DSCSA traceability frameworks for wholesale distributors.

"Amatheon's achievement is a testament to how compliance and innovation can go hand in hand," said Riya Cao, CEO of LSPedia. "Their vision sets a new benchmark for speed, transparency, and trust across global supply chains."

The Takeaway

Amatheon's story makes a case that's easy to overlook: compliance infrastructure, built right, doesn't just protect a business. It can improve it. For distributors juggling ERP limitations, manual tracking gaps, and mounting regulatory pressure, the real question isn't whether to modernize, but whether to treat that modernization as overhead or as an opportunity.

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